ProPresenter and ProVideoPlayer can be run simultaneously from the same Mac, but this is not recommended or supported. You will need to be proficient at assigning your outputs correctly in both programs in order for this to work. 

We do not have a recommended way of setting this up since this is not a supported setup.  We will always recommend two computers when running both programs simultaneously.

If you just need to have both programs installed on the same computer and you use them individually, then there won't be any issues at all with that.